Next Generation iCIEF

Name: Isogen Life Science B.V.
Address: Veldzigt 2a, De Meern, 3454 PW, NL
Telephone: +31 30 6880771

CEInfinite Imaged Capillary Isoelectric Focusing (iCIEF) Solutions

Isogen Life Science is the exclusive distributor of the CEInfinite Imaged Capillary Isoelectric Focusing (iCIEF) product line from AES (Advanced Electrophoresis Solutions Ltd). Since 2004 our company has been the Total CIEF Solution Provider for any (i)CIEF assays, supporting and delivering the Total CIEF Solutions to the European market.

For CE Solutions we offer the CAPEL Capillary Electrophoresis (CE) instruments.

The CEInfinite is a new generation WCTID CIEF system, standard equipped with a high sensitivity CMOS imaging sensor and powerful deep UV LED light source. CEInfinite dramatically increases the scan rate over 100 times compared to any other imaging time-resolved CIEF systems. It enables the study of fast dynamic processes more accurately, empowering Taylor dispersion rapid measurement of protein hydrodynamic radius, and protein interaction studies. Furthermore, it is the only WCTID CIEF system that enables you to perform direct coupling to MS for in depth characterisation studies and high resolution iCIEF fractionation for further studies like peptide mapping, SPR and biological assays.

CEInfinite iCIEF solutions provides you:

iCIEF faster method development, higher detection sensitivity, better reliability and higher analytical throughput
iCIEF automated high-resolution fractionation
iCIEF-MS, coupling with mass spectrometry
Method development services - we can perform your method development of any (i)CIEF assays
High resolution fractionation services - we can fractionise your samples
A comprehensive portfolio of carrier ampholytes, pI markers, cartridges and solutions for any i(CIEF) assays

We will help you out and provide you the best services that you need. We understand your needs.
Meet the Experts, Join our Team, Together, we can make it happen.

Learn more about:

Customer Reviews in fields like Proteomics and Pharma

Be updated with the newest publications

Attend our webinars about iCIEF protein characterization

Save time with our NEW CEInfinite Essential iCIEF System (Model M)

Our new CEInfinite Essential iCIEF instrument is equipped with a manual injection system. Therefore, it offers you:

High-resolution
High-throughput
Less time
Less resources

From now onwards, you can accelerate your project with simple workflows with our new Model M. It can be applied in fields like pharmaceutical, agricultural, environmental sciences, and many more.

CEInfinite Essential iCIEF Advantages

Fast sample injection < 1 min
Minimum sample injection of 2 μL
UV detection at 280 nm
Budget friendly
Compact size, 54x33x30 cm
CFR Title 21 Part 11 compliant

Download the CEInfinite Essential iCIEF System Brochure

Latest events

More events

Join the AES team at the WCBP 2023

Join the AES team at the "Well Characterized Biotechnology Pharmaceutical (WCBP)" Event 2023 to discover the recent innovations to overcome the challenges of biopharmaceutical development.

WEBINAR: Improve Resolution on iCIEF Characterization with AESlyte

Register now for our AES webinar about the new standard of characterizing complex fusion proteins: AESlyte carrier ampholytes (CAs). AESlyte can overcome the challenge of characterizing diverse, complex and fusion proteins. Join us to know why and how.

WEBINAR: Next generation iCIEF Technology for your Next-gen Biopharma

The Webinar covers breakthrough solutions to the main issues when using imaged capillary isoelectric focusing (iCIEF). Do you want to know how these technologies can accelerate the drug development process? Check the AES webinar about using iCIEF technology for your next-gen biopharma.

Customer Reviews

iCIEF in Pharmaceutics

“iCIEF plays a critical for monitoring charge variants during biopharmaceutical development. The CEInfinite allows us to get a mass readout for the product variants detected by iCIEF, and this is a great help for understanding the chemical nature of the charge variants.

When combining the CEInfinite with high resolution Orbitrap MS, detailed insight into product variants and product stability can be achieved.

In short, iCIEF MS using the CEInfinite is a very powerful characterisation tool in biopharmaceutical development.”

iCIEF-MS for Proteofroms

"The CEInfinite enables direct coupling of iCIEF to mass spectrometry, which is a powerful tool for the characterisation of proteoforms on the intact level.

The obtained high resolution mass spectra are of excellent quality - For me a surprisingly high quality even for intact mAbs although we use generic separation methods (standard ampholytes)."

Prof. Dr. Christian Neusüß, Hochschule Aalen

Quick and Easy iCIEF

"CEInfinite iCIEF instrument enables us to verify easily and quickly the behavior of the pI markers we have proposed.

The operation with the instrument is easy and the time for the separation in the order of minutes, while the same focusing task performed in the classical CE capillary equipment with pressure mobilization took hours."

Read his article: CE determination of the thermodynamic pK_a...

Why Isogen Life Science?

At Isogen Life Science, we believe that long term relationships with life science professionals and suppliers are fundamental to solve life science problems. Our curiosity drives us to continually stay involved and to dig deep in dialogue, with both clients and suppliers. It’s these intensive collaborations that enable us to develop tailored, innovative products that push life science’s boundaries. Partner up with us and enjoy our quick support for troubleshooting and questions!

Making your research happen.

Contact information

+31 30 6880771
support@isogen-lifescience.com

Our office

Veldzigt 2A
3454 PW De Meern

Next Generation iCIEF