Isogen Life Science is the exclusive distributor of the CEInfinite Imaged Capillary Isoelectric Focusing (iCIEF) product line from AES (Advanced Electrophoresis Solutions Ltd). Since 2004 our company has been the Total CIEF Solution Provider for any (i)CIEF assays, supporting and delivering the Total CIEF Solutions to the European market.
For CE Solutions we offer the CAPEL Capillary Electrophoresis (CE) instruments.
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“iCIEF plays a critical for monitoring charge variants during biopharmaceutical development. The CEInfinite allows us to get a mass readout for the product variants detected by iCIEF, and this is a great help for understanding the chemical nature of the charge variants.
When combining the CEInfinite with high resolution Orbitrap MS, detailed insight into product variants and product stability can be achieved.
In short, iCIEF MS using the CEInfinite is a very powerful characterization tool in biopharmaceutical development.”
PhD Dan Bach Kristensen, Principal Scientist
Symphogen
"The CEInfinite enables direct coupling of iCIEF to mass spectrometry, which is a powerful tool for the characterization of proteoforms on the intact level.
The obtained high resolution mass spectra are of excellent quality - For me a surprisingly high quality even for intact mAbs although we use generic separation methods (standard ampholytes)."
Prof. Dr. Christian Neusüß
Hochschule Aalen
"CEInfinite iCIEF instrument enables us to verify easily and quickly the behavior of the pI markers we have proposed.
The operation with the instrument is easy and the time for the separation in the order of minutes, while the same focusing task performed in the classical CE capillary equipment with pressure mobilization took hours."
Prof. Bohuslav Gaš
Charles University, Faculty of Science
Read his article: CE determination of the thermodynamic pKa...
Last April FHI organised a successful Life Science event together with several members. On one of the days, Dr. Rob Haselberg of the VU held a presentation on the protein characterisation of snake venom using the CEInfinite iCIEF. This is an innovative technique for Imaging Capillary Isoelectric Focusing.
“It was very interesting to discuss my results at FHI. It exposes you to a different audience and forces you to present your work in an accessible way; I truly enjoyed it. Moreover, it was great to show some of the initial data obtained with the CEInfinite iCIEF system. We really see the potential of this device in the characterization, fractionation, and affinity profiling of complex samples.”
Rob Haselberg
VU- BioAnalytische Chemie in Amsterdam
+31 30 6880771
support@isogen-lifescience.com
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