Isogen Life Science is the exclusive distributor of the CEInfinite Imaged Capillary Isoelectric Focusing (iCIEF) product line from AES (Advanced Electrophoresis Solutions Ltd). Since 2004 our company has been the Total CIEF Solution Provider for any (i)CIEF assays, supporting and delivering the Total CIEF Solutions to the European market.
For CE Solutions we offer the CAPEL Capillary Electrophoresis (CE) instruments.
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“iCIEF plays a critical for monitoring charge variants during biopharmaceutical development. The CEInfinite allows us to get a mass readout for the product variants detected by iCIEF, and this is a great help for understanding the chemical nature of the charge variants.
When combining the CEInfinite with high resolution Orbitrap MS, detailed insight into product variants and product stability can be achieved.
In short, iCIEF MS using the CEInfinite is a very powerful characterisation tool in biopharmaceutical development.”
"The CEInfinite enables direct coupling of iCIEF to mass spectrometry, which is a powerful tool for the characterisation of proteoforms on the intact level.
The obtained high resolution mass spectra are of excellent quality - For me a surprisingly high quality even for intact mAbs although we use generic separation methods (standard ampholytes)."
Prof. Dr. Christian Neusüß, Hochschule Aalen
"CEInfinite iCIEF instrument enables us to verify easily and quickly the behavior of the pI markers we have proposed.
The operation with the instrument is easy and the time for the separation in the order of minutes, while the same focusing task performed in the classical CE capillary equipment with pressure mobilization took hours."
Read his article: CE determination of the thermodynamic pKa...
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