The Innovator for Science

From Sample to Result

Platereading for Protein Aggregation

"We study the aggregation of proteins in relation to brain disorders, such as Alzheimer's disease. An important assay in our arsenal is the analysis of aggregation kinetics using fluorescent amyloid dyes. For this detection, we use the CLARIOstar and FLUOstar Omega plate-readers from BMG LABTECH, because of their robustness and reproducible data. Additionally, they are easy to use for postdocs as for students."

Prof. Dr. J. Schymkowitz,

VIB-KU Leuven, Center for Brain & Disease Research

Read the Article of Prof. Dr. Schymkowitz: Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments

Single Cell RNA Seq on head-neck tumour cells

“With the Nadia Instrument for Single Cell RNA-Sequencing we perform research on head and neck tumors. Currently, the response rate of immunotherapy for these tumors is low. We analyze the different anatomical locations, such as the oral cavity, hypopharynx, larynx and oropharynx.  Our goal is to better understand the tumor microenvironment of these tumors and eventually try to improve the response rate of immunotherapy. One approach to better understand the tumor microenvironment is single cell RNA-sequencing, where we study the mRNA content per single cell within the tumor microenvironment.

The Nadia Instrument provides a clear, well written protocol for single cell encapsulation and mRNA library Preparation. Additionally, quick service and support for questions and troubleshooting is provided.”

 T. Muijlwijk, Amsterdam UMC, Head and neck cancer biology & immunology (HNCBI) research group at the Department of Otolaryngology-head and neck surgery

NGPCR COVID Solution

Last January, our lab Laboratorio di Servicio implemented and validated the MBS’ NextGenPCR solution for CoV2 screening, in Aruba. We found this ultra-fast PCR technology easy to use, sensitive, specific and overall, really ultra-fast, both in throughput as well as time to result. Instead of the 300 tests a day, 1000 results per day were produced with a single NG-PCR system.

Robert Wever, director

Laboratoria di Servicio, Clinical Chemistry

RT-QuIC assays for protein aggregation

"We bought an extra FLUOstar Omega for our biomarker research. Part of my research focuses on the aggregation of alpha-synuclein, a protein involved in dementia with Lewy bodies and Parkinson’s disease.

With the Real-Time Quaking Induced Conversion (RT-QuIC) assay we can detect aggregates of alpha-synuclein in cerebrospinal fluid of patients.

The FLUOstar Omega plate reader makes it possible to perform these experiments, due to its options for prolonged interval shaking and maintaining constant temperature."

P. L. Hoede,

Neurochemistry Lab, Amsterdam UMC

Cellular Mechanism of Cancer Cells

"…With the new ClinoStar, we are able to maintain long-term 3D cell cultures that are used not only for tissue engineering approaches, but also to study the complex processes that allow a cancer cell to survive as a metastasis. This is critical for exploring new therapies to destroy cancer cells with metastatic properties. The ClinoStar will help to understand the cellular mechanisms that lead to metastasis in vitro and to develop anticancer countermeasures in vivo."

Dr. rer. nat. Marcus Krüger,

Medizinische Fakultät Universitätsklinikum Magdeburg

SAFE Tourism in Spain!

Mallorca, Lanzarote, Fuerteventura and Alicante airports are running COVID19 PCR tests with our fast RT-PCR solution: Results in less than 1 hour! It was a pleasure for me to install the NextGenPCR instrument solution at Eurofins Megalab COVID test centers.

Olga Burgos, NGS specialist and areamanager

Isogen Life Science

RNA Sequencing for Gene Regulation Analysis

"We aim to identify the up and down regulated genes in failing hearts. RNA sequencing with Lexogen technology helps us finding new therapeutic targets and Biomarkers."

"I am impressed by the high professionalism standards and the great collaboration between Isogen Life Science and Lexogen."

Dr. J. P. Aboumsallem

UMCG Cardiology Research Institute

iCIEF in Pharmaceutics

“iCIEF plays a critical for monitoring charge variants during biopharmaceutical development. The CEInfinite allows us to get a mass readout for the product variants detected by iCIEF, and this is a great help for understanding the chemical nature of the charge variants.

When combining the CEInfinite with high resolution Orbitrap MS, detailed insight into product variants and product stability can be achieved.

In short, iCIEF MS using the CEInfinite is a very powerful characterization tool in biopharmaceutical development.”

PhD Dan Bach Kristensen, Principal Scientist 

Symphogen

iCIEF-MS for Proteoforms

"The CEInfinite enables direct coupling of iCIEF to mass spectrometry, which is a powerful tool for the characterization of proteoforms on the intact level.

The obtained high resolution mass spectra are of excellent quality - For me a surprisingly high quality even for intact mAbs although we use generic separation methods (standard ampholytes)."

Prof. Dr. Christian Neusüß
Hochschule Aalen

Quick and Easy iCIEF

"CEInfinite iCIEF instrument enables us to verify easily and quickly the behavior of the pI markers we have proposed.

The operation with the instrument is easy and the time for the separation in the order of minutes, while the same focusing task performed in the classical CE capillary equipment with pressure mobilization took hours."

Prof. Bohuslav Gaš

Charles University, Faculty of Science

Read his article: CE determination of the thermodynamic pK_a...

Ion Analysis with CE

With the CAPEL CE you can analyse anions, cations, hormones, vitamins, proteins, organic and inorganic acids.

We mainly analyse the salivary ions and release of calcium ions from hydroxyapatite fronds after a short acid attack. Furthermore we also determine the uric acid in saliva.

We have been in possession of two CAPEL CE machines for over a year and we are very satisfied with these machines, the software is easy to use.

Ing Kamran Nazmi 

ACTA (Academisch Centrum Tandheelkunde Amsterdam)

Mutations Analysis in the Pancreas with Organoids

Our ongoing projects focus on the interplay between driver mutations and adaptation to acidic microenvironment in pancreatic ductal adenocarcinoma (PDAC), using spheroids and organoids as model systems. Organoids are stem cell-derived three-dimensional cell structures which genetically resemble their tissue of origin. Organoids derived from murine cancer models or patient tumours are valuable tools for precision medicine and drug development, however their standard culture method is expensive, time-consuming and low-throughput. We use the CelVivo ClinoStar system to grow spheroids and organoids quickly and in large quantities from small starting materials, mimicking in vivo-like intercellular communication, ultrastructure and metabolism. We also appreciate the potential that the ClinoStar system has for limiting the use of animal models in our research.

 Prof. Stine Falsing Pedersen,

Copenhagen University

Characterization, Fractionation, and Affinity Profiling of Complex Samples

“It was very interesting to discuss my results at FHI. It exposes you to a different audience and forces you to present your work in an accessible way; I truly enjoyed it. Moreover, it was great to show some of the initial data obtained with the CEInfinite iCIEF system. We really see the potential of this device in the characterization, fractionation, and affinity profiling of complex samples.”

Rob Haselberg

VU- BioAnalytische Chemie in Amsterdam