Success Story: The ClinoStar

Growing patient-derived organoids with the ClinoStar

Company:Tumor Screening Lab Research Group (Experimental Oncology Department at Antwerp University).

Project needs and our solution: Growing patient-derived organoids for pre-clinical and clinical development. The ClinoStar bioreactor enables to generation large size organoids removing shear forces, and therefor mimcking tumor environment. 

Key findings:The ClinoStar bioreactor enables:

  • Tumoroids adapt to in vitro culture conditions
  • Culture large size organoids to mimic patients
  • Generation of complex microtumor models


Experimental Oncology Department - Antwerpen University

The Experimental Oncology Department at the University of Antwertp is part of the Center for Oncological Research (CORE). The main goal undert he CORE operates is to advance cancer treatment and to improve patient quality of life through development of more efficient detection methods and new revolutionary therapies.

Prof. Christophe Deben is the Tumor Screening Lab Research group leader. He manages different projects where the main goal is to generate models to better study and understand cancer. The statement behind is to "help the patient, to find out the right drug for the right patient". 

Center for Oncological Research, University of Antwerp - At.Las


Mimic tumor environment for drug screening 

Organoids are not easy to grow. Therefore, oncology research groups need to find out those environment conditions where tumors are happy to grow to test in early and later stages drugs. The key point in the projects carried on in the department is to achieve patient-derived organoids for pre-clinical and clinical development. 

Workflow for the research

1. Access to patient samples from different tumor types. 

Fresh tissue is collected from tumor biopsies from the Antwertp University hospital (UZA). It is located close to the main department buidling, and samples are transported rapidly and efficiently to use for research purposes. 

The tumor fragments are directly incorporated in the ClinoStar. Then, after a specific time period they are fully adapted to the invitro cell culture conditions. Thanks to our bioreactor, organoids can grow in large sizes, which makes it to behavie closer to human diseases conditions. 

2. Biobanking and charachterising

Once organoids have arrived to ideal large sizes,  they need to live for a long-term time period and expand. Then, they are stored in biobanks. Biobanks standardize the collection and preservation of normal or pathological specimens, as well as related clinical information.

3. Develop high throughout drug screening assays: automated imageing and data analysis

Tumors from biobanking enable the study of disease modeling, new drug development and high-throughput drug screening

High throughput drug screening assays support drug development and clinical decision. From these assays, data is generated and analysed with the new analysis platform, Orbits.  

Have a look at the interview with Prof. Christophe Deben 

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