Functional Organoid Growth Technology 

Grow uniform spheroids and organoids in a standardised process.

This will give no bias in your research. With organoids and spheroids your research results will be more like in vivo. Organoid research, never been so easy with this standardised process.

The Clinostat can work with all kinds of cell cultures. Stem cell differentiations, brain, liver (hepatocytes), lung (bronchi), gut organoid/spheroid cultures and many more can be formed. Where 2D cells stop developing and growing 3D cells will continue to grow, develop, and interact with one other. This makes research on 3D cells more like in vivo. Additionally, less contamination is possible in the Clinostat, with automatic UV-decontamination, and do not have to open the system, due to the integrated camera. Take CELLfies and keep track of your cultures from remote. 1 tablet can view up to 50 different systems, which is 300 different incubations. Not needing to open and close the systems create a save and stable environment for your cultures. The humidity and CO2/O2 levels stay constant, and no shocks of opening and closing will affect your cells. This creates visible higher quality of your organoid and spheroid cell cultures.

Our experts will help you set up your workflow. You will get the system for a time, where you can see it for yourself.

Contact us if you want to test the system yourself

Clinostar reactor

Benefits of the Organoid Growth System

  • Large Spheroids and Organoid formation
  • Low shear stress, while maintaining active diffusion
  • Long time cell functionality
  • Unique airflow and filter system
  • Limits use of animal models
  • Ideal for cancer research, drug screening, stem cell research and many more applications

Ask your questions or request a quote.

Technology

The Clinostat uses gravity-free movements to create less shear forces, while maintaining active diffusion. This creates bigger and long-life organoid and spheroid cultures. The active diffusion allows for living cells in the core of the culture as on the outside of the culture. This way the organoid culture can interact with one other, as also occurs in organisms.

The vertical bioreactor has 6 individual incubators to grow your cells. CO2 level and temperature can be adjusted to optimise your cell growth. Even as the rotation speed, which can be adjusted individually per incubator. With the built-in fan, a uniform environment is created.

The system has a small footprint and is stackable up to 3 units, and therefore fits in any lab.

Bioreactor

In the clinostat, you have room for 6 disposable bioreactors. The outside of these reactors consists of hydro balls, which promotes the humidification and gas exchange. In the middle there is a 10 mL growth chamber (petri-dish) for your cell cultures. The circular reactors can stand vertical with an opening at the top for easy medium exchange. The front port allows for easy sampling of the organoids and spheroids.

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The ClinoReactor™
The ClinoReactor™

Celvivo technology has been used for cultivating:

  • Cryopreserved human primary hepatocytes
  • Immortal hepatoma cell line HepG2/C3A
  • Immortal hepatoma cell lines Huh-7
  • Immortalised hepatocytes (SV40 transformed): Fa2N-4
  • Human hepatic progenitor cell line: HepaRG
  • Human microvascular endothelial cell line: HMEC-1
  • Human monocyte Kupffer-cell-like cell line : THP-1
  • Human Colorectal adenocarcinoma cell line: LS180
  • Human adenocarcinoma cell line: HeLa
  • Human small cell lung cancer: NCI-H69 and sub clones
  • Rat insulinoma cell line: INS-1 and INS-1E
  • Rat islet cell line: RIN-m5F
  • Mouse pre-adipose embryo fibroblast cell line: 3T3-L1
  • Freshly isolated monkey (baboon) and rat islets of Langerhans
  • Freshly isolated human colon cancer biopsies 

We can send you the applications.
Contact us if you want to know more!

Customer Reviews

Customer review

Cellular Mechanism of Cancer Cells

"With the new ClinoStar, we are able to maintain long-term 3D cell cultures that are used not only for tissue engineering approaches, but also to study the complex processes that allow a cancer cell to survive as a metastasis. This is critical for exploring new therapies to destroy cancer cells with metastatic properties. The ClinoStar will help to understand the cellular mechanisms that lead to metastasis in vitro and to develop anticancer countermeasures in vivo."

Customer review

Mutation Analysis of the Pacreas with Organoids

The Pedersen team investigates acid-base- and metabolite homeostasis in cancer development, metabolism and invasiveness. We combine state-of-the-art 3D cell culture with live imaging, mouse models, molecular- and computational biology.

Our ongoing projects focus on the interplay between driver mutations and adaptation to acidic microenvironment in pancreatic ductal adenocarcinoma (PDAC), using spheroids and organoids as model systems. Organoids derived from murine cancer models or patient tumours are valuable tools for precision medicine and drug development, however their standard culture method is expensive, time-consuming and low-throughput. We use the CelVivo ClinoStar system to grow spheroids and organoids quickly and in large quantities from small starting materials, mimicking in vivo-like intercellular communication, ultrastructure and metabolism. We also appreciate the potential that the ClinoStar system has for limiting the use of animal models in our research.

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Contact information

+31 30 6880771
support@isogen-lifescience.com

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Veldzigt 2A
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