3D Cell Culture

Mimic In Vivo Conditions with 3D models

Grow organoids and spheroids in an environment that better reflects human biology

Traditional static cell culture often struggles to reproduce the complex interactions found inside living tissues. Cells are exposed to artificial mechanical forces, nutrient gradients and limited oxygen diffusion, resulting in models that may not accurately predict in vivo behaviour.

The ClinoStar® uses clinostat technology to create a low-shear, dynamically suspended culture environment where spheroids and organoids can develop more naturally, helping researchers generate more physiologically relevant and reproducible models.

Talk to our 3D Cell Culture Specialists

Key benefits for your research:

• More physiologically relevant model: Support 3D tissue growth in conditions that better mimic the in vivo environment.
• Healthier long-term cultures: Improve nutrient and oxygen exchange to support viable spheroids and organoids over extended culture periods.
• Reduced shear stress: Keep cultures gently suspended without harsh agitation or mechanical damage.
• Improved reproducibility: Create more consistent culture conditions across experiments and users.
• Larger and more complex 3D models: Support the development of advanced organoids and spheroids with improved morphology and functionality.
• Better translational relevance: Generate models that can better support drug discovery, disease modelling, toxicology and regenerative medicine research.

How Clinostat Technology Works

The ClinoStar combines a precision CO₂ incubator with rotating bioreactors (ClinoReactors) based on the clinostat principle. Rather than allowing cells to settle at the bottom of the culture vessel, the ClinoReactor continuously rotates, counterbalancing gravitational forces and keeping spheroids and organoids suspended in a gentle orbit.