News
OpenSPR-XT system in Nature
Obi, J.O., Kihn, K.C., McQueen, L. et al. Structural dynamics of the dengue virus non-structural 5 (NS5) interactions with promoter stem-loop A (SLA). npj Viruses 3, 30 (2025). https://doi.org/10.1038/s44298-025-00112-1
University of Maryland researchers used our desktop OpenSPR-XT system to watch dengue-virus NS5 clamp onto its 5′-UTR promoter. The full enzyme bound at ≈ 14 nM kD, about 10× tighter than its separate domains, proving the domains need each other.
Why OpenSPR-XT made it easier?
- Label-free, low-volume/maintenance: only 200 µL per injection—no tags, no complex system.
- Hands-free: up to 24 h automated runs keep data flowing while you’re away.
- Publication-ready kinetics in hours, dovetailing with HDX-MS & cryo-EM
- Benchtop & budget-friendly, trusted by 500 + labs worldwide.
OpenSPR slots right into studies on viral polymerases (SARS-CoV-2, Zika, Flu), RNA–protein binding, or CRISPR guide interactions, delivering real-time on/off rates before lunch.
