CEInfinite High Sensitive Detection

CEInfinite High Sensitive Detection by using High Performance icIEF Cartridges

The traditional icIEF cartridge is limited by the small inner diameter of the separation capillary, there is always an unmet need of higher absorbance detection sensitivity in Capillary Electrophoresis. The detection sensitivity of an icIEF detection depends on both detection wavelength as well as the inner diameter of the separation column.

We provide a customised icIEF detection at 280nm that gives you about 5 folds higher sensitivity detection in comparison to other imaging  and conventional CIEF detection at 214nm. In addition our High Performance icIEF cartridges are 200µm ID, which provides you 100% sensitivity improvements over 100µm ID (standard use with other icIEF instruments) and 300% over 50µm that are standard use in traditional CIEF assays.

The High-Performance icIEF cartridges are available in four types of different coatings for your assays. The great advantage if using PA and AD coatings, there is no need of methyl cellulose additive makes your Research/QC work simpler in comparison to the standard FC (i)cIEF coating.


Contact us for more information, let's discuss the best approach for your research together!



Main Benefits and Overview of our available cartridges coatings

Available in three types of different coatings for your applications. Great advantage there is no need of Methyl 
Cellulose additive makes your Research/QC work simpler:

Fluorocarbon (FC) based capillary coating (coating thickness 0.1 µm)

  • Standard CIEF coating
  • Suitable for pH 2-11
  • Methyl cellulose additive necessary for hydration of the coating 

Polyacrylamide (PA) based capillary coating (molecular layer coating)

  • No methyl cellulose additive necessary
  • Popular CIEF coating

Acrylamide derivative (AD) capillary coating (molecular layer coating)

  • Highly reliable
  • More stable than PA
  • No methyl cellulose additive necessary#
  • Specially developed for preparative iCIEF
  • Can be coupled directly to ESI-

Overview of the CEInfinite High Performance icIEF Cartridges

The CEInfinite High Performance icIEF cartridges are the world’s first WCID imaging cartridges enables direct coupling to a mass spectrometer.

In addition we offer many and different column coatings to be used for icIEF assays, such as special coatings for hydrophilic and hydrophobic molecules besides the fluorocarbon coating that is typical used for general icIEF applications.

Learn more about: Implementation of Highly Efficient Protein Characterization and Preparative icIEF

  • These cartridges deliver high sensitivity and performance.
  • The easy flow along the capillary makes for simpler, faster sample injection with less clogging.
  • Available in various inner diameters for better sensitivity and capacity.

Please note that these can be used with other icIEF instruments. For additional information, please do not hesitate to contact us.

Contact us for any question, let's discuss it together!

Permanent methylcellulose coated cartridges 

Our new permanent methylcellulose coated cartridges enables you to perform icIEF free from polymers. Therefore, the characterisation of any protein drug product is now possible straight forward.

Discover the benefits you would have: 

  • Free Methylcellulose in pre-rinse and sample running.
  • High repeatability.
  • High separation efficiency.

In addition, the icIEF separation in the MC coated cartridge can be compared with the routine coated cartridge of the fluorocarbon (FC), to ensure consistency in drug discovery.

Comparison FC versus MC coated cartridge

The MC coated capillary cartridge has applied to icIEF-MS for characterising protein charged variants with reliable identification of MS after icIEF separation:

  • Simple the operation steps.
  • Prevent contamination of MS ESI.

As a result, we have now a breakthrough in icIEF-MS to greatly improve the compatibility with MS.

Custom Made Solution Services

Custom made cartridges with different coatings and/or ID can be offered upon request. Please contact us for further support on this custom made solution services.

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