Imaged capillary isoelectric focusing (iCIEF) tandem high-resolution mass spectrometry for charged heterogeneity of protein drugs in biopharmaceutical discovery

Xiaoxi Zhang, Teresa Kwok, Mike Zhou, Min Du,  Victor Li, Tao Bo, Tiemin Huang, Tong Chen
Journal of Pharmaceutical and Biomedical Analysis 224 (2023) 115178



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Cutting-edge mass spectrometry strategy based on imaged capillary isoelectric focusing (icIEF) technology for characterizing charge heterogeneity of monoclonal antibody
Xiaoxi Zhang, Tong Chen, Victor Li, Tao Bo, Min Du, Tiemin Huang
Analytical Biochemistry, Volume 660, 1 January 2023, 114961




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White paper: Critical reagents for successful iCIEF

Advanced Electrophoresis Solutions Ltd., October, 2022





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Characterization of therapeutic mAb charge heterogeneityby iCIEF coupled to mass spectrometry (iCIEF–MS)

Johannes Schlecht, Bernd Moritz, Steffen Kiessig, Christian Neusüß September23, 2022




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Global characterization of modifications to the charge isomers of IgG antibody

Xinling Cui, Wei Mi, Zhishang Hu, Xiaoyu Li, Bo Meng, Xinyuan Zhao,Xiaohong Qian, Tao Zhu, Wantao Ying
Journal of Pharmaceutical Analysis, 12 (2022) 156-163




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High-Efficiency Preparative Imaged Capillary Isoelectric Focusing (iCIEF) and iCIEF-MS Protein Charge Variant Characterisation

Tong Chen, Teresa Kwok, Anne Rose Esmin, Victor Li, Gerard Rozing,Tiemin Huang
Chromatography, May / June 2021




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High-Throughput Precision with On-Board Mixing for Imaged Capillary Isoelectric Focusing (iCIEF)

Katelyn Cousteils, Jennifer Hu, Victor Li, Tiemin Huang Chromatography, February / March 2019






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Coupling imaged capillary isoelectric focusing with mass spectrometry using a nanoliter valve

Faculty of Chemistry, Aalen University, Aalen, Germany
Electrophoresis, 2018DOI 10.1002/elps.201800013





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Determination of the isoelectric point of shortened glucagon-like peptide-1 by capillary isoelectric focusing with whole column imaging

Junjian Fang*, Jiexin Liu*, Haijing Li, Jianhua Cheng, Shengming Wu, and Fangting Dong





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