Capillary Electrophoresis Applications

Capillary Electrophoresis Applications

The CAPEL Capillary Electrophoresis (CE) instruments are robust, compact, and well design to be used as Dedicated Analysers for several dedicated solutions in the fields of Biopharma, Environmental Analysis, Chemical Industry, Food Testing, Animal feeding and Veterinary.

Besides these dedicated solutions, you can use both CAPEL CE instruments for developing your own specific assay(s) based CZE, CGE, CIEF, MEKC, CE-SDS and so on.

All assays that are described in the monographs or general chapters from pharmacopoeias can be executed on the CAPEL CE instruments.

Both CAPEL CE instruments are user-friendly for operation, so you can also use them as a simple CE tool to get familiar with CE technology.

As being Total Solution Provider for CE Solutions, we can help you with developing your assays. We will provide you the best services that you need.

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Biopharma 

The CAPEL CE instruments can be used use a versatile Analytical Tool for developing assays in BioPharma that are based on capillary zone electrophoresis (CZE), capillary gel electrophoresis (CGE), capillary isoelectric focusing (CIEF), micellar electrokinetic chromatography (MEKC) and CE-SDS.

All assays that are described in the monographs or general chapters from pharmacopoeias can be executed on the CAPEL CE instruments.

Here below you find a selection of several Biopharma applications.

Determination of proteins concentrations and their molecular weights

Compared with protein separation with SDS-Page, using our method give you several advantages:

  • Full automatization
  • Direct protein quantification
  • Absence of coloring
  • Short analysis time
  • Low analysis cost

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Determination of product-related impurities in recombinant therapeutic monoclonal antibodies 

The method is based on Capillary Gel Electrophoresis and executed according to the USP129 and CH.P 3127. It is also possible to run CE-SDS on the CAPEL-205 Routine Analyser.

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Determination of aprotinin impurities in aprotinin and aprotinin concentrated solution 

The method is based on Capillary Zone Electrophoresis and executed according to the EP monographs 0579 and 0580.

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QC and Process (Fermentation Control) 

Accurate analysis of fermentation liquid for the presence of inorganic anions, or cations, or organic acids can be of utmost importance to ensure the correct way of the whole  process.

For example, the elevated values of acetic acid can indicate certain deviations in the technology of fermentation, phosphates are important for the microorganism’s vitality and so on.

Our analytical protocol allows you to detect the target compounds in a fermentation liquid in all kinds of fields (BioPharma, Food Industry and so on)

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Environment Analysis 

The CAPEL CE instruments can be used as Dedicated Analysers for several environmental assays. We have several analytical protocols (SOPs) available for the determination of inorganic cations, organic acids, water chlorination products and several other groups of compounds (herbicides, pesticides and so on).

Here below you find a selection of several environmental applications.

Determination of inorganic anions in aqueous matrices 

The method is based on capillary zone electrophoresis and executed according to EPA 6500 and ASTM D6508-10. The method can be used for the analyses of drinking water, wastewater and ground water.

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Determination of chlorate, perchlorate and chlorate ions in drinking and bottled water 

Chlorination is the most widespread way of disinfecting water in the world. Due to high toxicity the maximum permitted levels (MPL) are determined in WHO Guidelines for drinking water.

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Determination of water-soluble forms of inorganic cations in soils, clays, peat and many more 

The water-soluble forms of inorganic cations, such as ammonium, potassium, calcium, sodium, magnesium, are one of the substantial characteristics in agrochemical, land reclamation and sanitary assessments of soils. During ecological soil monitoring the cation balance is to be controlled for the human activity impact assessment.

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Chemical Industry 

The CAPEL CE instruments can be used as Dedicated Analysers for several chemical industrial assays. We have several analytical protocols (SOPs) available for the determination of inorganic cations, inorganic anions, organic acids and so on.

Here below you find a selection of several chemical industrial applications.

Determination of acetic acid (acetate anions) in natural, drinking and wastewater 

The method is based on the sample filtration and dilution. Measurement is done with  indirect anions detection at 266 nm.

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Determination of inorganic anions and organic acids from traces of corrosion 

Traces of corrosion are taken from the metal surface and extracted in water (a corrosion study (UN project).

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Determination of Inorganic cations in wastewater from industrial region 

Our analytical protocol allows you to detect the target compounds in wastewater.

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Food Testing

The CAPEL CE instruments can be used as Dedicated Analysers for several food assays. We have several analytical protocols (SOPs) available for the determination of inorganic cations, inorganic anions, organic acids and so on.

Here below you find a selection of several food applications

Determination of synthetic amino acids (methionine, threonine and tryptophan) in fodder additives 

Our instrument kit allows you to measure the synthetic amino acids. The method is based on CZE with direct UV detection.

Furthermore our instrument kit allows you also to determine free lysine and methionine hydroxy analogue (HMTBa) in fodder additives.

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Identification and determination of synthetic dyes in soft and alcoholic drinks 

Our method allows you to identify and determine several synthetic dyes. These includes Tartrazine, Sunset Yellow FCF, Carmoisine, Amaranth, Ponceau 4R, Erythrosine, Red 2G, Allure Red AC, Patent Blue V, Indigotine, Brilliant Blue FCF, Green C and Brilliant Black BN.

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Determination of D- and L-isomers of tartaric and malic acids in wines, wine materials and food additives 

Our methods allows you to determine D- and L-isoforms of tartaric and malic acids in all types of wines, wine materials, and special food additives.

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Animal feeding and Veterinary 

The CAPEL CE instruments can be used as Dedicated Analysers for several food assays. We have several analytical protocols (SOPs) available for the determination of inorganic cations, inorganic anions, organic acids and so on.

Here below you find a selection of several applications.

Determination of anions in feed stuffs, compound feed and feed raw materials 

Our method allows you to measure water-soluble chloride, nitrate, phosphate and sulphate in all types of feed stuffs, compound feeds, fodders, premixes, fodder additives and feed raw materials (from plant, animal and mineral origin).

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Determination of whey proteins in milk samples by CGE 

Our method allows you to determine whey proteins in milk samples. Various ofvarious β-lactoglobulin isoforms can be determined in a short time.

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